Trazodonum
| Cognitores | |
|---|---|
| ChemSpider | 5332 |
| PubChem | 5533 |
| DrugBank | DB00656 |
| Natura chemica | |
| |
| |
| Formula summarum | Formula:Chem |
| Massa molaris | 371.8641 g/mol |
| Natura pharmacologica | |
| Codex ATC | Formula:ATC |
| Metabolismus | iecore (hepaticus): CYP3A4 |
| Tempus semivitae biologicum | 7 h |
| Excretio | renibus (70-75%) faecibus 21% |
| Ad usum therapeuticum | |
| Applicatio | per os |
| MedlinePlus | a681038 Formula:Ling |
Trazodonum est ad depressionem tractandem medicamentum cum effectibus antidepressivis.
Natura Trazodoni
Natura chemica
Trazodolum est piperazinum. Structura chemica est 2-{3-[4-(3-chloro-phenylo)-piperazino-1-yl]-propylo}-[1,2,4]triazolo-[4,3-a]pyridino-3-onum.
Massa molaris est 371.8641 g/mol.
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2H-1,2,3-Triazolum -
Natura pharmacologica
Trazodonum est antidepressivum cum effectibus antidepressivis et sedativis. Codex ATC est N06AX05.
Pharmacodynamica
Substantia imprimis transportatores serotonini et receptoria 5-HT2a ac α1 inhibit.
| Receptorium | Trazodoni affinitas ligandi, Ki (nM)[1] |
Actio |
|---|---|---|
| α1 | 12-42 | |
| α1A | 153 | |
| α2 | 106-490 | |
| 5-HT2A | 20–45 | |
| SERT | 160–>10,000 |
Pharmacocinetica
Tempus semivitae biologicum est circa 7 horae.[2] Trazodonum substratum cytochromatum CYP3A4 est. Excretio est dodrante per urinas, at 20% per faeces.