Fontem paginae Trazodonum inspicere

{{cautio}}
{| class="wikitable floatright"
|+ '''Trazodonum'''
|-
! colspan="2" | Cognitores
|-
| style="font-size: 85%" | ''[[ChemSpider]]'' || style="font-size: 85%" | [http://www.chemspider.com/Chemical-Structure.5332.html 5332]
|-
| style="font-size: 85%" | [[PubChem]] || style="font-size: 85%" | [https://pubchem.ncbi.nlm.nih.gov/compound/5533 5533]
|-
| style="font-size: 85%" | [[DrugBank]] || style="font-size: 85%" | [https://www.drugbank.ca/drugs/DB00656 DB00656]
|-
! colspan="2" | Natura chemica
|-
| style="text-align: center" colspan="2" | [[Fasciculus:Trazodone.svg|250px|Trazodonum]]
|-
| style="text-align: center" colspan="2" | [[Fasciculus:Trazodone-from-HCl-xtal-3D-balls.png|250px|Trazodonum]]
|-
| style="font-size: 85%" | [[Formula chemica|Formula summarum]] || style="font-size: 85%" | {{chem|C|19|H|22|Cl|N|5|O}}
|-
| style="font-size: 85%" | [[Massa molaris]] || style="font-size: 85%" | 371.8641 g/mol
|-
! colspan="2" | Natura pharmacologica
|-
| style="font-size: 85%" | Codex ATC || style="font-size: 85%" | {{ATC|N06AX|05}}
|-
| style="font-size: 85%" | [[Metabolismus]] || style="font-size: 85%" | [[iecur|iecore]] (hepaticus):<br />[[CYP3A4]]
|-
| style="font-size: 85%" | [[Tempus semivitae biologicum]] || style="font-size: 85%" | 7 h
|-
| style="font-size: 85%" | Excretio || style="font-size: 85%" | [[ren]]ibus (70-75%)<br />faecibus 21%
|-
! colspan="2" | Ad usum therapeuticum
|-
| style="font-size: 85%" | Applicatio || style="font-size: 85%" | per os
|-
| style="font-size: 85%" | MedlinePlus || style="font-size: 85%" | [https://medlineplus.gov/druginfo/meds/a681038.html a681038] {{Ling|Anglice}}
|}
'''Trazodonum''' est ad [[depressio (psychiatria)|depressionem]] tractandem [[medicamentum]] cum effectibus antidepressivis. 

== Natura Trazodoni ==
=== Natura chemica ===
Trazodolum est [[piperazinum]]. Structura chemica est 2-{3-[4-(3-[[chlorum|chloro]]-phenylo)-[[piperazinum|piperazino]]-1-yl]-propylo}-[1,2,4]triazolo-[4,3-''a''][[pyridinum|pyridino]]-3-onum.

Massa molaris est 371.8641 g/mol.

<gallery>
Fasciculus:Piperazine Structural Formula V1.svg|[[Piperazinum]]
Fasciculus:2H-1,2,3-Triazole Structural FormulaV.1.svg|2''H''-1,2,3-[[Triazolum]]
Fasciculus:Pyridine.svg|[[Pyridinum]]
</gallery>

=== Natura pharmacologica ===
Trazodonum est [[antidepressivum]] cum effectibus antidepressivis et sedativis. [[Systema classificationis Anatomicum Therapeuticum Chemicumque|Codex ATC]] est [[Codex ATC N06AX|N06AX]]05. 

=== Pharmacodynamica ===
Substantia imprimis [[transportator serotonini|transportatores serotonini]] et receptoria [[receptorium serotonini 2A|5-HT<sub>2a</sub>]] ac [[receptorium adrenergicum alpha-1|α<sub>1</sub>]] inhibit.
{| class="wikitable floatright" style="font-size:small;"
|-
! [[Receptorium neurotransmissoris|Receptorium]] !! Trazodoni affinitas<br />ligandi, ''K''<sub>i</sub> (nM)<ref>https://web.archive.org/web/20131108013656/http://pdsp.med.unc.edu/pdsp.php</ref>!! Actio
|-
| [[Receptorium adrenergicum alpha-1|α<sub>1</sub>]] || 12-42 ||  
|-
| [[Receptorium adrenergicum alpha-1|α<sub>1A</sub>]] || 153 ||  
|-
| [[Receptorium adrenergicum alpha-2|α<sub>2</sub>]] || 106-490 ||  
|-
|  [[Receptorium serotonini 2A|5-HT<sub>2A</sub>]] || 20–45 ||  
|-
|  [[Transportator serotonini|SERT]] || 160–>10,000 || 
|}

=== Pharmacocinetica ===
[[Tempus semivitae biologicum]] <math>t_{\frac{1}{2}}</math> est circa 7 horae.<ref>[http://goldbook.iupac.org/B00658.html Fons.]</ref> Trazodonum [[substratum (Chemia)|substratum]] [[Cytochroma P450|cytochromatum]] [[CYP3A4]] est. Excretio est dodrante per [[urina]]s, at 20% per faeces.

== Notae ==
<references />

{{NexInt}} 
* [[Pharmacologia]]
* [[Serotoninum]]

== Nexus externi ==
* [https://pharmacycode.com/Trazodonum_%5BLatin%5D.html Referentia nominis Latini].

[[Categoria:Piperazina]]
[[Categoria:Antidepressiva]]